About Me
William (Bill) Biagio Guggino

Professor and Director of Physiology
Vice-Chair for Research in Pediatrics
The Johns Hopkins University School of Medicine
Department of Physiology
725 N. Wolfe Street
Baltimore, Maryland 21205
Phone: (410) 955-7166
Email: wguggino@jhmi.edu


Brooklyn College - Brooklyn, NY; B.S. 1969 Biology
Long Island University - C.W. Post College; M.S.
University of North Carolina - Chapel Hill, NC; Ph.D. 1978 Zoology
Yale Medical School - New Haven, CT; Fellow 1982 Renal Physiology


William B. Guggino has dedicated more than two decades of his professional life to The Johns Hopkins University School and Medicine, and as of May 2006 been appointed as the new Director of Physiology. Bill's commitment to science and to the School is equaled only by the passion he has for teaching, and for the mentoring of the brilliant students who have been fortunate enough to study and work with him.

Among his many contributions to Hopkins, Bill has served since 1996 as Vice Chairman of Research in the Department of Pediatrics and since 1989 as Director of the Cystic Fibrosis Development Program. His own work on CF was recognized last year when he won the prestigious Doris F. Tulcin Cystic Fibrosis Research Award, an honor that marked not only his research achievements, but also his role in the training of a significant number of clinician scientists dedicated to the unraveling of CF's mysteries and brining new treatments to patients quickly.

In 1992, Bill, along with Peter Agre, M.D., authored a seminal paper published in Science, which detailed the discovery of the very first water channel protein. That line of research, 11 years later, won Agre the Nobel Prize in Chemistry.

For 24 years, Bill has been the course director in organ systems physiology and histology and has served as the Director of Curriculum for First Year Medical Students. He is also a former recipient of the Hopkins Excellence in Teaching Award.

Research Interests

Current research interests include ion channels, gene therapy, polycystic kidney disease, epithelial cell biology, protein trafficking and localization, and cystic fibrosis. Presently, investigating the structure and function of Cl- and water channels; trafficking and molecular organization of transport proteins in epithelial cell membranes; and genetic therapies for the correction of defective ion transport in CF cells and patients. Research is also being conducted on the identification of the specific defect in Cl- channel regulation in patients with Cystic Fibrosis, the most common autosomal recessive disease in North America.


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