William B. Guggino has
dedicated more than two decades of his professional life to The Johns
Hopkins University School and Medicine, and as of May 2006 been
appointed as the new Director of Physiology. Bill's commitment to
science and to the School is equaled only by the passion he has for
teaching, and for the mentoring of the brilliant students who have been
fortunate enough to study and work with him.
Among his many contributions to Hopkins, Bill has served since 1996
as Vice Chairman of Research in the Department of Pediatrics and since
1989 as Director of the Cystic Fibrosis Development Program. His own
work on CF was recognized last year when he won the prestigious Doris
F. Tulcin Cystic Fibrosis Research Award, an
honor that marked not only his research achievements, but also his role
in the training of a significant number of clinician scientists
dedicated to the unraveling of CF's mysteries and brining new
treatments to patients quickly.
1992, Bill, along with Peter Agre, M.D.,
authored a seminal paper published in Science, which detailed the discovery
of the very first water channel protein. That line of research, 11
years later, won Agre the Nobel Prize in
For 24 years, Bill has been the course director in
organ systems physiology and histology and has served as the Director
of Curriculum for First Year Medical Students. He is also a former
recipient of the Hopkins Excellence in Teaching Award.
Current research interests include ion channels, gene
therapy, polycystic kidney disease, epithelial cell biology, protein
trafficking and localization, and cystic fibrosis. Presently,
investigating the structure and function of Cl-
and water channels; trafficking and molecular organization of transport
proteins in epithelial cell membranes; and genetic therapies for the
correction of defective ion transport in CF cells and patients.
Research is also being conducted on the identification of the specific
defect in Cl- channel regulation in patients
with Cystic Fibrosis, the most common autosomal
recessive disease in North America.
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