Publications

·         Wang SX, Ikeda M, & Guggino WB (2003). The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression. J Biol Chem 278, 2713-2722.

·         Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, Fujiyoshi Y, Engel A, & Nielsen S (2002). Aquaporin water channels--from atomic structure to clinical medicine. J Physiol 542, 3-16.

·         Beck SE, Laube BL, Barberena CI, Fischer AC, Adams RJ, Chesnut K, Flotte TR, & Guggino WB (2002). Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques. Mol Ther 6, 546-554.

·         Cheng J, Moyer BD, Milewski M, Loffing J, Ikeda M, Mickle JE, Cutting GR, Li M, Stanton BA, & Guggino WB (2002). A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. J Biol Chem 277, 3520-3529.

·         Devuyst O & Guggino WB (2002). Chloride channels in the kidney: lessons learned from knockout animals. Am J Physiol Renal Physiol 283, F1176-F1191.

·         Edmonds RD, Silva IV, Guggino WB, Butler RB, Zeitlin PL, & Blaisdell CJ (2002). ClC-5: ontogeny of an alternative chloride channel in respiratory epithelia. Am J Physiol Lung Cell Mol Physiol 282, L501-L507.

·         Hazama A, Kozono D, Guggino WB, Agre P, & Yasui M (2002). Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation. J Biol Chem 277, 29224-29230.

·         Ikeda M & Guggino WB (2002). Do polycystins function as cation channels? Curr Opin Nephrol Hypertens 11, 539-545.

·         Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, & Yasui M (2002). Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. J Biol Chem 277, 39873-39879.

·         Ketchum CJ, Yue H, Alessi KA, Devidas S, Guggino WB, & Maloney PC (2002). Intracellular cysteines of the cystic fibrosis transmembrane conductance regulator (CFTR) modulate channel gating. Cell Physiol Biochem 12, 1-8.

·         Lebeau C, Hanaoka K, Moore-Hoon ML, Guggino WB, Beauwens R, & Devuyst O (2002). Basolateral chloride transporters in autosomal dominant polycystic kidney disease. Pflugers Arch 444, 722-731.

·         Ornellas DS, Nascimento DS, Christoph DH, Guggino WB, & Morales MM (2002). Aldosterone and high-NaCl diet modulate ClC-2 chloride channel gene expression in rat kidney. Pflugers Arch 444, 193-201.

·         Schwiebert EM, Wallace DP, Braunstein GM, King SR, Peti-Peterdi J, Hanaoka K, Guggino WB, Guay-Woodford LM, Bell PD, Sullivan LP, Grantham JJ, & Taylor AL (2002). Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Renal Physiol 282, F763-F775.

·         Swiatecka-Urban A, Duhaime M, Coutermarsh B, Karlson KH, Collawn J, Milewski M, Cutting GR, Guggino WB, Langford G, & Stanton BA (2002). PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 277, 40099-40105.

·         Wagner JA, Nepomuceno IB, Messner AH, Moran ML, Batson EP, Dimiceli S, Brown BW, Desch JK, Norbash AM, Conrad CK, Guggino WB, Flotte TR, Wine JJ, Carter BJ, Reynolds TC, Moss RB, & Gardner P (2002). A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum Gene Ther 13, 1349-1359.

·         Boyle MP, Enke RA, Adams RJ, Guggino WB, & Zeitlin PL (2001). In utero AAV-mediated gene transfer to rabbit pulmonary epithelium. Mol Ther 4, 115-121.

·         Guggino WB (2001). Cystic fibrosis salt/fluid controversy: in the thick of it. Nat Med 7, 888-889.

·         Milewski MI, Mickle JE, Forrest JK, Stafford DM, Moyer BD, Cheng J, Guggino WB, Stanton BA, & Cutting GR (2001). A PDZ-binding motif is essential but not sufficient to localize the C terminus of CFTR to the apical membrane. J Cell Sci 114, 719-726.

·         Morales MM, Nascimento DS, Capella MA, Lopes AG, & Guggino WB (2001). Arginine vasopressin regulates CFTR and ClC-2 mRNA expression in rat kidney cortex and medulla. Pflugers Arch 443, 202-211.

·         Boletta A, Qian F, Onuchic LF, Bhunia AK, Phakdeekitcharoen B, Hanaoka K, Guggino W, Monaco L, & Germino GG (2000). Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells. Mol Cell 6, 1267-1273.

·         Guggino WB & Guggino SE (2000). Amiloride-sensitive sodium channels contribute to the woes of the flu. Proc Natl Acad Sci U S A 97, 9827-9829.

·         Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, & Germino GG (2000). Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408, 990-994.

·         Hanaoka K & Guggino WB (2000). cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells. J Am Soc Nephrol 11, 1179-1187.

·         Hryciw DH & Guggino WB (2000). Cystic fibrosis transmembrane conductance regulator and the outwardly rectifying chloride channel: a relationship between two chloride channels expressed in epithelial cells. Clin Exp Pharmacol Physiol 27, 892-895.

·         Morales MM, Capella MA, Sanches MV, Lopes AG, & Guggino WB (2000). Modulation of the mdr-1b gene in the kidney of rats subjected to dehydration or a high-salt diet. Pflugers Arch 439, 356-362.

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